Dietinduced atherosclerosis hypercholesterolemia in. Latitudinal patterns in phenotypic plasticity and fitnessrelated traits. Conventional and phylogenetic informed analyses indicated a positive correlation between metabolic scope and geographic latitude. Unlike larger animals, mice have a short gestational period, are genetically similar, often give birth to many offspring at once and can be housed as multiple groups in a. Latitudinal patterns in phenotypic plasticity and fitness. D2550 3701m081 metabolic cage for rats over 300g all included without stand. We measured the basal metabolic rate bmr and body temperature t b patterns of naturally warmacclimated, freshly captured adult longtailed bigfooted mice macrotarsomys ingens 67. Interplay between global patterns of environmental temperature and variation in nonshivering thermogenesis of rodent species across large spatial scales.
Testing the metabolic homeostasis hypothesis in amphibians. Enatural history note latitudinal patterns in rodent. Latitudinal patterns in phenotypic plasticity and fitnessrelated. Ecological plasticity may index the capacity of individuals, populations, and species to respond to stochasticity.
To date, animal models of obesity based on gene modi. Dietinduced atherosclerosis hypercholesterolemia in rodent models 2008 brief scienti. Species geographical distributions are tracking latitudinal and elevational surface temperature gradients under global climate change. Assessing the climatic variability hypothesis cvh with an invasive plant species. To allow consistency with historical client research we provide any commercially. Translate your antiobesity agent to the clinic with crownbios models and services. Mice provide the most ideal animal model for studies of potential therapies. Latitudinal variation in lifespan within species is. Different studies in the literature use c57bl 6j mice and consider the followup time greater than 15 weeks to obesity induced by high fat diet.
Pdf latitudinal patterns in rodent metabolic flexibility. Crownbios preclinical cardiovascular and metabolic disease cvmd translational technology platforms provide a full suite of rodent models for obesity research and development, and for evaluation of antiobesity agents. It is caused by a number of risk factors and leads to. Aaschool of marine and atmospheric sciences, stony brook university, stony brook, ny 117945000, abschool of marine and atmospheric sciences, stony brook university, stony brook, ny 117945000. Faster refer to the table of human metabolic rates in the lab. In analyses restricted to rodents 34 species, neither log body mass alone ols r2. Metabolic rates of least and pectoral sandpipers at a stopover site during spring migration. Nutrition in rodents and lagomorphs merck veterinary manual. Conventional and phylogenetic informed analyses indicated a positive correlation between metabolic scope and geographic. Moreover, correlation coefficients ranging between 0. Linear regression of standardized, phylogenetically independent contrasts was used to describe the allometric relationship between admr and body mass in rodents. D2551 3701m071 metabolic cage for rats under 300g all included without stand.
To control these diseases, research in rodent models that closely mimic. Ro dent mo del for the study of obesityrelated disor ders rev assoc med bras 2012. Ms was induced by administration of fructose as 10% solution in drinking water for 8 weeks. For example, in a recent study across rodent species, metabolic scope was negatively correlated with both t min and torpid body temperature, suggesting that selection on the depth and duration of torpor may influence latitudinal patterns of metabolic scope careau 20. Pdf latitudinal patterns in phenotypic plasticity and. The case of seasonal flexibility in lizards fat body size. Highfat diets for dietinduced obesity models in order to gain a greater understanding of human obesity, rats and mice are commonly used models as they will readily gain weight when provided with a highfat diet and also develop other risk factors associated with the ms. Effects of brassica rapa on fructoseinduced metabolic. Within this framework, here we evaluate the existence of latitudinal patterns in fat body size flexibilityestimated as the difference between maximum and minimum fat body size values observed throughout a yearfor 59 lizard species, comprising the first evaluation of the cvh for a trait, other than thermic or metabolic characters, in.
Rodents are widely used to mimic human diseases to improve understanding of the causes and progression of disease symptoms and to test potential therapeutic interventions. Chronic diseases such as obesity, diabetes and hypertension, together known as the metabolic syndrome, are causing increasing morbidity and mortality. This study aimed to elucidate the role of turnip brassica rapa on fructoseinduced metabolic syndrome. However, there are considerable practical limitations to including such. Faster than humans refer to the table of human metabolic rates in the lab. The amount of hormone is related to metabolic alterations such as leptin and adiponectin, it is higher in female, thus influencing in the food and energy intake, as well as weight gain interfering 26. I used a recently compiled dataset on vo 2sum elicited by cold exposure in a mixture of helium and oxygen i. Latitudinal pattern in rodent metabolic flexibility completo, 2012. Thus, disentangling general patterns in phenotypic flexibility, which could be then included in models aimed to predict changes in species distribution, represent a central goal in the current ecological agenda. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and wellbeing around the world. Increased fructose consumption is strongly associated with incidence of metabolic syndrome ms. Atherosclerosis is a complex chronic disease characterized by the accumulation of lipids within arterial walls that eventually go on to form plaques, which can cause. Two different patterns of digestive flexibility have been described for vertebrates, one for species in which metabolic costs of homeostasis are relatively high and the gut is rarely empty e. D600429 3m01d100 single cage stand ss mm 310x310x340.
The heat balance and human metabolism define the following. Body mass and water economy in the south american olivaceous fieldmouse along a latitudinal gradient. A number of hypotheses about compensatory mechanisms that allow ectothermic animals to cope with the latitudinal decrease in ambient temperature t a have been proposed during the last century. All animals were exposed to a 12hour light12hour dark cycle. Calculated metabolic rate of rodent calhrm 2 calculation. These findings, together with previous reports on latitudinal pattern in phenotypic flexibility, suggest that an increase in physiological flexibility with latitude may be hold for many phenotypic traits. In this context, we evaluate the correlation between absolute metabolic scope during cold exposure an instantaneous measure of metabolic flexibility and different geographic and climatic variables for 48 rodent species. The energetics of a malagasy rodent, macrotarsomys ingens. Latitudinal patterns in rodent metabolic flexibility article pdf available in the american naturalist 1796. Lactating mice mus musculus exhibit compensatory flexibility in gut morphology in response to reduced dietary protein. Compare rodent metabolic rate to that of male and female humans.
Latitudinal patterns in rodent metabolic flexibility the. Interplay between global patterns of environmental temperature and variation in nonshivering thermogenesis of rodent species across large spatial scales enrique rodriguez. Naya,1,2, lucia spangenberg,3 hugo naya,3 and francisco bozinovic2 1. Pdf physiological correlates of geographic range in animals. From left to right plots are log geographic range size vs. Latitudinal patterns in rodent metabolic flexibility. Rodent male female metabolic rate 5443 5300 5062 age na 6. D2548 3m02d100 rack ss 12 cages 360037003701 verticle type 1240x480x1900h mm. Rodent models of obesity research and drug discovery. Interplay between global patterns of environmental. Hugo naya and francisco bozinovic, latitudinal patterns in rodent metabolic flexibility, the american naturalist, 179, 6, e172, 2012.
Overall, phenotypic plasticity increased with latitude for all six traits. Methods and models for metabolic assessment in mice. Disentangling environmental drivers of metabolic flexibility in birds. Differences between temperate and tropical birds in. How does your metabolic rate compare with that of the rodent. Basal metabolic rate, maximum thermogenic capacity and.
Additionally, msum was a better predictor of latitudinal patterns of metabolic scope than bmr, with. Latitudinal patterns in rodent metabolic flexibility pp. The diurnal pattern of dna synthesis in young rats 28 to 35 days was investigated under various feeding regimens of a normal and a proteindeficient diet. Department of biology, loyola university maryland, 4501 north charles street, baltimore, md 21210, usa. To control these diseases, research in rodent models that closely mimic the changes in humans is essential. To evaluate the opportunities to track these gradients across space, we provide a first baseline assessment of the steepness of these gradients for the worlds terrestrial birds. Naya, lucia spangenberg, hugo naya and francisco bozinovic doi. These findings, together with previous reports on latitudinal pattern in phenotypic flexibility, suggest that an increase in physiological flexibility with latitude may hold for many phenotypic traits.
Average daily metabolic rate admr is the metabolizable energy intake required by a caged animal to maintain constant body energy content. E1729 june 2012 with 70 reads how we measure reads. Maximum oxygen consumption and heat loss facilitation in. Bozinovic f 2012 latitudinal patterns in rodent metabolic flexibility. In addition to vo 2sum, this dataset includes a measure of bmr or resting metabolic rate rmr in the same population and, when possible, in the same. Testing the climatic variability hypothesis with data on the intestinal length of rodents daniel e. The development of new therapies for the treatment of type 2 diabetes requires robust, reproducible and well validated in vivo experimental systems. One of these hypotheses, the metabolic homeostasis hypothesis mhh, states that species should show the highest thermal sensitivity of the metabolic rate q 10smr at the colder end. Ecological plasticity of denning chronology by american.